Lyon, France-Traditionally, national and international DNA databases have been forced to rely on strict rules, often dropping potentially valuable investigative leads when DNA profiles are incomplete or only partially matched.

Until now.

Interpol's DNA team worked with Smart Research BV to develop a smarter way to review DNA matches.

Instead of adopting the traditional one-size-fits-all rule based on at least six matching DNA markers, we have developed a new dynamic likelihood ratio threshold calculation method. This new method allows for the automatic detection of potential DNA database matches based on only three markers.

This innovative approach opens up new lines of investigation, enabling decisions to be made in real time, taking into account the richness of DNA markers, the rarity of genetic profiles and the size of the database retrieved. As a result, previously "invisible" matches can now be identified, and cold cases gain new investigative leads-while ensuring that false positives are tightly controlled.

This scalable and transparent approach promises to significantly enhance the global DNA database without increasing operational burden.

Cyril Gott, Interpol's Director of Operational Support and Analysis, said:

"By sharing these open access tools at national central bureaux, Interpol continues to support member countries in responding to complex investigations and promoting international police cooperation."